Mark Griffiths

Mark Griffiths

Email Mark Rheolwr Ymchwil a Datblygu Iechyd y Cyhoedd

Er 2008, mae Mark Griffiths wedi gweithio i Public Health England (yr Asiantaeth Diogelu Iechyd yn flaenorol) ac mae bellach yn Rheolwr Ymchwil a Datblygu yng Nghyfarwyddiaeth Polisi, Ymchwil a Datblygu Rhyngwladol Iechyd Cyhoeddus Cymru. Mae’n arwain y gwaith o weithredu Strategaeth Ymchwil Iechyd Cyhoeddus Cymru sydd yn amlinellu’r blaenoriaethau a’r ymrwymiadau i Iechyd  Cyhoeddus Cymru feithrin diwylliant fydd yn caniatáu creu syniadau ymchwil newydd ac arfer gorau wedi ei lywio gan dystiolaeth. Mae hefyd yn bennaeth ar y Swyddfa YaD sydd yn rheoli llywodraethu ymchwil ar gyfer y sefydliad. Mae’n cynrychioli Iechyd Cyhoeddus Cymru ar Fforwm GIG Cymru ar gyfer Rheoli Ymchwil a Datblygu mewn Iechyd a Gofal Cymdeithasol (FORWARD) a Grŵp Cymorth a Chyflenwi Ymchwil Iechyd a Gofal Cymru.

Mae gan Mark brofiad helaeth mewn ymchwil rhyngwladol a rheoli prosiectau ym maes rheoli peryglon amgylcheddol iechyd y cyhoedd yn cynnwys datblygu canllawiau, systemau rhybuddio’n gynnar, olrhain a gwyliadwriaeth, ac asesu’r bygythiad a’r perygl i iechyd yn sgil baich clefydau o beryglon amgylcheddol. Mae wedi rheoli prosiectau ac wedi cyfrannu at arbenigedd technegol i dendrau amrywiol wedi eu hariannu gan DG SANCO a FP7, prosiectau ac ymarferion ymchwil yn cynnwys y Rhwydwaith Asesu’r perygl Cemegol ac Ymbelydredd; Datblygu System Rybuddio ar gyfer Datblygu Systemau Gwyliadwraeth Iechyd ar gyfer Bygythiadau Iechyd (ASHT); Ymateb Iechyd y Cyhoedd i’r pecyn cymorth Argyfyngau Digwyddiadau Cemegol, Safoni Dulliau Dadansoddi Labordai ac Ymarfer Quicksilver. Roedd Mark yn olygydd gwadd ar gyfer rhifyn arbennig yn y cyfnodolyn Environment International (Cyfrol 72, Tachwedd 2014).

Cyfeiriadau Dethol

  1. Duarte-Davidson R, Orford R, Wyke S, Griffiths M, Amlôt R, Chilcott R. Recent advances to address European Union Health Security from cross border chemical health threats. Environ Int. 2014 Nov;72:3-14. doi: 10.1016/j.envint.2014.01.003. Epub 2014 Mar 27. 

  2. Duarte-Davidson R, Griffiths M, Wyke S, Bradley N. Recent developments in assessing and managing serious health threats. Environ Int. 2014 Nov;72:1-2. doi: 10.1016/j.envint.2014.06.001. Epub 2014 Jun 24.

  3. Schaper A, Desel H, Wyke S, Orford R, Griffiths MR, Edwards N, Kupferschmidt H, Mathieu M, Pelclova D, Duarte-Davidson R. Countering health threats by chemicals with a potential terrorist background--creating a rapid alert system for Europe. Eur J Intern Med. 2012 Mar;23(2):e63-6. doi: 10.1016/j.ejim.2011.09.015. Epub 2011 Oct 26.

  4. Griffiths M.R, Gasque P, Neal J.W The Regulation of the CNS Innate Immune Response is Vital for the Restoration of Tissue Homeostasis (Repair) after Acute Brain Injury: A Brief Review, International Journal of Inflammation, vol. 2010, Article ID 151097, 18 pages, 2010. doi:10.4061/2010/151097.

  5. Griffiths MR, Neal JW, Fontaine M, Das T, Gasque P. Complement factor H, a marker of self protects against experimental autoimmune encephalomyelitis. J Immunol. 2009 Apr 1;182 (7):4368-77.
     
  6. Griffiths M.R, Gasque P, Neal J.W. The multiple roles of the innate immune system in the regulation of apoptosis and inflammation in the brain, J Neuropathol Exp Neurol. 2009 Mar;68 (3):217-26.

  7. Griffiths M, Neal JW, Gasque P. Innate immunity and protective neuroinflammation: new emphasis on the role of neuroimmune regulatory proteins. Griffiths M, Neal JW, Gasque P. Int Rev Neurobiol. 2007;82:29-55. Review. 

  8. Jean-François Jégou, Philippe Chan, Marie-Thérèse Schouft, Mark R. Griffiths, James W. Neal, Philippe Gasque, Hubert Vaudry and Marc Fontaine. C3d Binding to the Myelin Oligodendrocyte Glycoprotein Results in an Exacerbated Experimental Autoimmune Encephalomyelitis, Journal of Immunology (2007, 178(5):3323-31).

  9. Tambourgi DV, Pedrosa MF, de Andrade RM, Billington SJ, Griffiths M, van den Berg CW. Sphingomyelinases D induce direct association of C1q to the erythrocyte membrane causing complement mediated autologous haemolysis. Mol Immunol. 2006 Mar 13 

  10. Hauwel, M., Furon, E., Canova, C., Griffiths, M., Neal, J., Gasque, P. Innate (inherent) control of brain infection, brain inflammation and brain repair: the role of microglia, astrocytes, “protective” glial stem cells and stromal ependymal cells. Brain Res. Rev, 2005, April, 48 (2)220-233. 

  11. Elward K, Griffiths M, Mizuno M, Harris CL, Neal JW, Morgan BP, Gasque P. CD46 plays a key role in tailoring innate immune recognition of apoptotic and necrotic cells. J Biol Chem. 2005 Aug 8

  12. Mead, R.J., Neal J.W., Griffiths, M.R., Linington, C., Botto, M., Lassman, H. and Morgan, B.P., Deficiency of the complement regulator CD59a enhances disease severity, demyelination and axonal injury in murine acute experimental allergic encephalomyelitis.

  13. Lab Invest. 2004 Jan; 84(1): 21-8.

  14. Morgan BP, Griffiths M, Khanom H, Taylor SM, Neal JW, Blockade of the C5a receptor fails to protect against experimental autoimmune encephalomyelitis in rats Clin Exp Immunol. 2004 Dec;138(3):430-8. 

  15. Mitchell I.J. and Griffiths, M.R., The differential susceptibility of specific neuronal populations: insights from Huntington's disease. IUBMB Life. 2003 Jun; 55(6): 293-8.

  16. Mitchell, I.J., Cooper, A.C, Griffiths, M.R. and Cooper, A.J., Acute administration of haloperidol induces apoptosis of neurones in the striatum and substantia nigra in the rat. Neuroscience. 2002; 109(1): 89-99. 

  17. Haynes, L. E., Griffiths, M. R., Hyde, R. E., Barber, D. J. and Mitchell, I. J., Dexamethasone induces limited apoptosis and extensive sublethal damage to specific subregions of the striatum and hippocampus: implications for mood disorder, Neuroscience. 104, 1 (2001) 57-69.

  18. Griffiths, M.R., Cooper, A.J., Barber, D.J. and Mitchell, I.J., Pharmacological mechanisms mediating phencyclidine-induced apoptosis of striatopallidal neurons: the roles of glutamate, dopamine, acetylcholine and corticosteroids, Brain Research, 855 (2000) 1-10. 

  19. Griffiths, M.R., Mitchell, I.J. and Cooper, A.J.,  Phencyclidine induces D1 dopamine receptor mediated Fos like immunoreactivity in discretely localised populations of striatopallidal and striatoentopeduncular neurons in the rat. Brain Research, 821,(1999) 177-189.  

  20. Mitchell I.J., Cooper A.J. and Griffiths M.R. The selective vulnerability of striatopallidal neurons. Progress in Neurobiology, 59,(1999) 691-719. 

  21. Mitchell, I.J., Cooper, A.J., Griffiths, M.R. and Barber, D.J., Phencyclidine and corticosteroids induce apoptosis of a subpopulation of striatal neurons: A neural substrate for psychosis? Neuroscience 84, 2, (1998) 489-501.