Mark Griffiths

Mark Griffiths

Email Mark Public Health Research and Development Manager

Since 2008, Mark Griffiths has worked for Public Health England (formerly the Health Protection Agency) and is now the Research and Development Manager within Public Health Wales’ Policy, Research and International Development Directorate. He leads on the implementation of the Public Health Wales’ Research Strategy which outlines the priorities and commitments for Public Health Wales to foster a culture that will allow for the generation of new research ideas and evidence-informed best practice. He also heads the R&D Office which manages research governance for the organisation. He represents Public Health Wales on the Forum of NHS Wales for Research & Development Management in Health and Social Care (FORWARD) and the Health and Care Research Wales Support and Delivery Operational Group.

Mark has extensive experience in international research and project management in the area of public health management of environmental hazards including the development of guidance, early warning, tracking and surveillance systems, and health threat and risk assessment of the burden of disease from environmental hazards. He has project managed and contributed technical expertise to various DG SANCO and FP7 funded tenders, research projects and exercises including the Chemical and Radiation Risk Assessment Network; Development of an Alerting System and the Criteria for Development of a Health Surveillance System for Health Threats (ASHT); The Public Health Response to Chemical Incident Emergencies toolkit, the Standardisation of Laboratory Analytical Methods and Exercise Quicksilver. Mark was guest editor for a special edition in the journal Environment International (Volume 72, November 2014).

Selected References:

  1. Duarte-Davidson R, Orford R, Wyke S, Griffiths M, Amlôt R, Chilcott R. Recent advances to address European Union Health Security from cross border chemical health threats. Environ Int. 2014 Nov;72:3-14. doi: 10.1016/j.envint.2014.01.003. Epub 2014 Mar 27. 

  2. Duarte-Davidson R, Griffiths M, Wyke S, Bradley N. Recent developments in assessing and managing serious health threats. Environ Int. 2014 Nov;72:1-2. doi: 10.1016/j.envint.2014.06.001. Epub 2014 Jun 24.

  3. Schaper A, Desel H, Wyke S, Orford R, Griffiths MR, Edwards N, Kupferschmidt H, Mathieu M, Pelclova D, Duarte-Davidson R. Countering health threats by chemicals with a potential terrorist background--creating a rapid alert system for Europe. Eur J Intern Med. 2012 Mar;23(2):e63-6. doi: 10.1016/j.ejim.2011.09.015. Epub 2011 Oct 26.

  4. Griffiths M.R, Gasque P, Neal J.W The Regulation of the CNS Innate Immune Response is Vital for the Restoration of Tissue Homeostasis (Repair) after Acute Brain Injury: A Brief Review, International Journal of Inflammation, vol. 2010, Article ID 151097, 18 pages, 2010. doi:10.4061/2010/151097.

  5. Griffiths MR, Neal JW, Fontaine M, Das T, Gasque P. Complement factor H, a marker of self protects against experimental autoimmune encephalomyelitis. J Immunol. 2009 Apr 1;182 (7):4368-77.
     
  6. Griffiths M.R, Gasque P, Neal J.W. The multiple roles of the innate immune system in the regulation of apoptosis and inflammation in the brain, J Neuropathol Exp Neurol. 2009 Mar;68 (3):217-26.

  7. Griffiths M, Neal JW, Gasque P. Innate immunity and protective neuroinflammation: new emphasis on the role of neuroimmune regulatory proteins. Griffiths M, Neal JW, Gasque P. Int Rev Neurobiol. 2007;82:29-55. Review. 

  8. Jean-François Jégou, Philippe Chan, Marie-Thérèse Schouft, Mark R. Griffiths, James W. Neal, Philippe Gasque, Hubert Vaudry and Marc Fontaine. C3d Binding to the Myelin Oligodendrocyte Glycoprotein Results in an Exacerbated Experimental Autoimmune Encephalomyelitis, Journal of Immunology (2007, 178(5):3323-31).

  9. Tambourgi DV, Pedrosa MF, de Andrade RM, Billington SJ, Griffiths M, van den Berg CW. Sphingomyelinases D induce direct association of C1q to the erythrocyte membrane causing complement mediated autologous haemolysis. Mol Immunol. 2006 Mar 13 

  10. Hauwel, M., Furon, E., Canova, C., Griffiths, M., Neal, J., Gasque, P. Innate (inherent) control of brain infection, brain inflammation and brain repair: the role of microglia, astrocytes, “protective” glial stem cells and stromal ependymal cells. Brain Res. Rev, 2005, April, 48 (2)220-233. 

  11. Elward K, Griffiths M, Mizuno M, Harris CL, Neal JW, Morgan BP, Gasque P. CD46 plays a key role in tailoring innate immune recognition of apoptotic and necrotic cells. J Biol Chem. 2005 Aug 8

  12. Mead, R.J., Neal J.W., Griffiths, M.R., Linington, C., Botto, M., Lassman, H. and Morgan, B.P., Deficiency of the complement regulator CD59a enhances disease severity, demyelination and axonal injury in murine acute experimental allergic encephalomyelitis.

  13. Lab Invest. 2004 Jan; 84(1): 21-8.

  14. Morgan BP, Griffiths M, Khanom H, Taylor SM, Neal JW, Blockade of the C5a receptor fails to protect against experimental autoimmune encephalomyelitis in rats Clin Exp Immunol. 2004 Dec;138(3):430-8. 

  15. Mitchell I.J. and Griffiths, M.R., The differential susceptibility of specific neuronal populations: insights from Huntington's disease. IUBMB Life. 2003 Jun; 55(6): 293-8.

  16. Mitchell, I.J., Cooper, A.C, Griffiths, M.R. and Cooper, A.J., Acute administration of haloperidol induces apoptosis of neurones in the striatum and substantia nigra in the rat. Neuroscience. 2002; 109(1): 89-99. 

  17. Haynes, L. E., Griffiths, M. R., Hyde, R. E., Barber, D. J. and Mitchell, I. J., Dexamethasone induces limited apoptosis and extensive sublethal damage to specific subregions of the striatum and hippocampus: implications for mood disorder, Neuroscience. 104, 1 (2001) 57-69.

  18. Griffiths, M.R., Cooper, A.J., Barber, D.J. and Mitchell, I.J., Pharmacological mechanisms mediating phencyclidine-induced apoptosis of striatopallidal neurons: the roles of glutamate, dopamine, acetylcholine and corticosteroids, Brain Research, 855 (2000) 1-10. 

  19. Griffiths, M.R., Mitchell, I.J. and Cooper, A.J.,  Phencyclidine induces D1 dopamine receptor mediated Fos like immunoreactivity in discretely localised populations of striatopallidal and striatoentopeduncular neurons in the rat. Brain Research, 821,(1999) 177-189.  

  20. Mitchell I.J., Cooper A.J. and Griffiths M.R. The selective vulnerability of striatopallidal neurons. Progress in Neurobiology, 59,(1999) 691-719. 

  21. Mitchell, I.J., Cooper, A.J., Griffiths, M.R. and Barber, D.J., Phencyclidine and corticosteroids induce apoptosis of a subpopulation of striatal neurons: A neural substrate for psychosis? Neuroscience 84, 2, (1998) 489-501.